by Gabriel López-Peña, Eva Ortiz-Mansilla, Antonio Arranz, Nicoleta Bogdan, Miguel Manso-Silván and Emma Martín Rodríguez
Abstract:
Today, diabetes mellitus is one of the most common diseases that affects the population on a worldwide scale. Patients suffering from this disease are required to control their blood-glucose levels several times a day through invasive methods such as piercing their fingers. Our NaGdF4: 5% Er3+, 3% Nd3+ nanoparticles demonstrate a remarkable ability to detect D-glucose levels by analysing alterations in their red-to-green ratio, since this sensitivity arises from the interaction between the nanoparticles and the OH groups present in the D-glucose molecules, resulting in discernible changes in the emission of the green and red bands. These luminescent sensors were implemented and tested on paper substrates, offering a portable, low-cost and enzyme-free solution for D-glucose detection in aqueous solutions with a limit of detection of 22 mg/dL. With this, our study contributes to the development of non-invasive D-glucose sensors, holding promising implications for managing diabetes and improving overall patient well-being with possible future applications in D-glucose sensing through tear fluid.
Reference:
Gabriel López-Peña, Eva Ortiz-Mansilla, Antonio Arranz, Nicoleta Bogdan, Miguel Manso-Silván and Emma Martín Rodríguez, “Non-invasive paper-based sensors containing rare-earth-doped nanoparticles for the detection of D-glucose”, Colloids and Surfaces B: Biointerfaces, vol. 239, pp. 113934.
Bibtex Entry:
@article{lopez-pena_non-invasive_2024,
title = {Non-invasive paper-based sensors containing rare-earth-doped nanoparticles for the detection of {D}-glucose},
volume = {239},
issn = {0927-7765},
url = {https://www.sciencedirect.com/science/article/pii/S0927776524001930},
doi = {10.1016/j.colsurfb.2024.113934},
abstract = {Today, diabetes mellitus is one of the most common diseases that affects the population on a worldwide scale. Patients suffering from this disease are required to control their blood-glucose levels several times a day through invasive methods such as piercing their fingers. Our NaGdF4: 5% Er3+, 3% Nd3+ nanoparticles demonstrate a remarkable ability to detect D-glucose levels by analysing alterations in their red-to-green ratio, since this sensitivity arises from the interaction between the nanoparticles and the OH groups present in the D-glucose molecules, resulting in discernible changes in the emission of the green and red bands. These luminescent sensors were implemented and tested on paper substrates, offering a portable, low-cost and enzyme-free solution for D-glucose detection in aqueous solutions with a limit of detection of 22 mg/dL. With this, our study contributes to the development of non-invasive D-glucose sensors, holding promising implications for managing diabetes and improving overall patient well-being with possible future applications in D-glucose sensing through tear fluid.},
urldate = {2024-05-21},
journal = {Colloids and Surfaces B: Biointerfaces},
author = {López-Peña, Gabriel and Ortiz-Mansilla, Eva and Arranz, Antonio and Bogdan, Nicoleta and Manso-Silván, Miguel and Martín Rodríguez, Emma},
month = jul,
year = {2024},
keywords = {Enzyme-free sensor, Glucose detection, Luminescent sensor, Non-invasive sensing, Paper-based sensor, Up-converting nanoparticles},
pages = {113934},
file = {López-Peña et al. - 2024 - Non-invasive paper-based sensors containing rare-e.pdf:E:\Usuarios\Administrator\Zotero\storage\MZELX6WB\López-Peña et al. - 2024 - Non-invasive paper-based sensors containing rare-e.pdf:application/pdf;ScienceDirect Snapshot:E:\Usuarios\Administrator\Zotero\storage\PBT4DKCX\S0927776524001930.html:text/html},
}