by Marta Ibáñez-Moragues, Irene Fernández-Barahona, Rocío Santacruz, Marta Oteo, Víctor M. Luján-Rodríguez, María Muñoz-Hernando, Natalia Magro, Juan I. Lagares, Eduardo Romero, Samuel España, Andrea Espinosa-Rodríguez, Miguel García-Díez, Víctor Martínez-Nouvilas, Víctor Sánchez-Tembleque, José Manuel Udías, Víctor Valladolid-Onecha, Miguel Á Martín-Rey, Edilia I. Almeida-Cordon, Sílvia Viñals i Onsès, José Manuel Pérez, Luis Mario Fraile, Fernando Herranz and Miguel Ángel Morcillo
Abstract:
Proton therapy allows the treatment of specific areas and avoids the surrounding tissues. However, this technique has uncertainties in terms of the distal dose fall-off. A promising approach to studying the proton range is the use of nanoparticles as proton-activatable agents that produce detectable signals. For this, we developed an iron oxide nanoparticle doped with Zn (IONP@Zn-cit) with a hydrodynamic size of 10 nm and stability in serum. Cytotoxicity, defined as half of the surveillance, was 100 μg Zn/mL in the U251 cell line. The effect on clonogenic cell death was tested after X-ray irradiation, which suggested a radioprotective effect of these nanoparticles at low concentrations (1–10 μg Zn/mL). To evaluate the production of positron emitters and prompt-gamma signals, IONP@Zn-cit was irradiated with protons, obtaining prompt-gamma signals at the lowest measured concentration (10 mg Zn/mL). Finally, 67Ga-IONP@Zn-cit showed accumulation in the liver and spleen and an accumulation in the tumor tissue of 0.95% ID/g in a mouse model of U251 cells. These results suggest the possibility of using Zn nanoparticles as proton-activatable agents to verify the range by prompt gamma detection and face the challenges of prompt gamma detection in a specific biological situation, opening different avenues to go forward in this field.
Reference:
Marta Ibáñez-Moragues, Irene Fernández-Barahona, Rocío Santacruz, Marta Oteo, Víctor M. Luján-Rodríguez, María Muñoz-Hernando, Natalia Magro, Juan I. Lagares, Eduardo Romero, Samuel España, Andrea Espinosa-Rodríguez, Miguel García-Díez, Víctor Martínez-Nouvilas, Víctor Sánchez-Tembleque, José Manuel Udías, Víctor Valladolid-Onecha, Miguel Á Martín-Rey, Edilia I. Almeida-Cordon, Sílvia Viñals i Onsès, José Manuel Pérez, Luis Mario Fraile, Fernando Herranz and Miguel Ángel Morcillo, “Zinc-Doped Iron Oxide Nanoparticles as a Proton-Activatable Agent for Dose Range Verification in Proton Therapy”, Molecules, vol. 28, no. 19, pp. 6874.
Bibtex Entry:
@article{ibanez-moragues_zinc-doped_2023,
title = {Zinc-{Doped} {Iron} {Oxide} {Nanoparticles} as a {Proton}-{Activatable} {Agent} for {Dose} {Range} {Verification} in {Proton} {Therapy}},
volume = {28},
copyright = {http://creativecommons.org/licenses/by/3.0/},
issn = {1420-3049},
url = {https://www.mdpi.com/1420-3049/28/19/6874},
doi = {10.3390/molecules28196874},
abstract = {Proton therapy allows the treatment of specific areas and avoids the surrounding tissues. However, this technique has uncertainties in terms of the distal dose fall-off. A promising approach to studying the proton range is the use of nanoparticles as proton-activatable agents that produce detectable signals. For this, we developed an iron oxide nanoparticle doped with Zn (IONP@Zn-cit) with a hydrodynamic size of 10 nm and stability in serum. Cytotoxicity, defined as half of the surveillance, was 100 μg Zn/mL in the U251 cell line. The effect on clonogenic cell death was tested after X-ray irradiation, which suggested a radioprotective effect of these nanoparticles at low concentrations (1–10 μg Zn/mL). To evaluate the production of positron emitters and prompt-gamma signals, IONP@Zn-cit was irradiated with protons, obtaining prompt-gamma signals at the lowest measured concentration (10 mg Zn/mL). Finally, 67Ga-IONP@Zn-cit showed accumulation in the liver and spleen and an accumulation in the tumor tissue of 0.95% ID/g in a mouse model of U251 cells. These results suggest the possibility of using Zn nanoparticles as proton-activatable agents to verify the range by prompt gamma detection and face the challenges of prompt gamma detection in a specific biological situation, opening different avenues to go forward in this field.},
language = {en},
number = {19},
urldate = {2023-12-15},
journal = {Molecules},
author = {Ibáñez-Moragues, Marta and Fernández-Barahona, Irene and Santacruz, Rocío and Oteo, Marta and Luján-Rodríguez, Víctor M. and Muñoz-Hernando, María and Magro, Natalia and Lagares, Juan I. and Romero, Eduardo and España, Samuel and Espinosa-Rodríguez, Andrea and García-Díez, Miguel and Martínez-Nouvilas, Víctor and Sánchez-Tembleque, Víctor and Udías, José Manuel and Valladolid-Onecha, Víctor and Martín-Rey, Miguel Á and Almeida-Cordon, Edilia I. and Viñals i Onsès, Sílvia and Pérez, José Manuel and Fraile, Luis Mario and Herranz, Fernando and Morcillo, Miguel Ángel},
month = jan,
year = {2023},
keywords = {zinc, iron oxide nanoparticles, irradiation, nanoparticle, prompt gamma radiation, proton range verification, proton therapy, radiotherapy},
pages = {6874},
file = {Full Text PDF:E:\Usuarios\Administrator\Zotero\storage\Q9YBWMD2\Ibáñez-Moragues et al. - 2023 - Zinc-Doped Iron Oxide Nanoparticles as a Proton-Ac.pdf:application/pdf},
}