by R. Magro Hernández, A. Muñoz-Noval, J. A. Briz, J. R. Murias, A. Espinosa-Rodríguez, L. M. Fraile, F. Agulló-Rueda, M. D. Ynsa, C. Tavares de Sousa, B. Cortés-Llanos, G. García López, E. Nácher, V. García-Tavora, N. Mont i Geli, A. Nerio, V. V. Onecha, M. Pallàs, A. Tarifeño, O. Tengblad, M. Manso Silván and S. Viñals
Abstract:
Osteosarcoma is a radioresistant cancer, and proton therapy is a promising radiation alternative for treating cancer with the advantage of a high dose concentration in the tumor area. In this work, we propose the use of iodine-substituted hydroxyapatite (IHAP) nanomaterials to use iodine (127I) as a proton radiation tracer, providing access to range verification studies in mineralized tissues. For this purpose, the nanomaterials were synthesized at four iodine concentrations via hydrothermal synthesis. The materials were characterized via different microstructural techniques to identify an optimal high iodine concentration and pure apatite phase nanomaterial. Finally, such pure IHAP powders were shaped and irradiated with proton beams of 6 and 10 MeV, and their activation was demonstrated through subsequent decay analysis. The materials could be integrated into phantom structures for the verification of doses and ranges of protons prior to animal testing and clinical proton therapy treatments of tumors located deep under combined soft and calcified tissues.
Reference:
R. Magro Hernández, A. Muñoz-Noval, J. A. Briz, J. R. Murias, A. Espinosa-Rodríguez, L. M. Fraile, F. Agulló-Rueda, M. D. Ynsa, C. Tavares de Sousa, B. Cortés-Llanos, G. García López, E. Nácher, V. García-Tavora, N. Mont i Geli, A. Nerio, V. V. Onecha, M. Pallàs, A. Tarifeño, O. Tengblad, M. Manso Silván and S. Viñals, “Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy”, Journal of Materials Chemistry B.
Bibtex Entry:
@article{hernandez_iodine-substituted_2024,
title = {Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy},
issn = {2050-7518},
url = {https://pubs.rsc.org/en/content/articlelanding/2024/tb/d4tb01391c},
doi = {10.1039/D4TB01391C},
abstract = {Osteosarcoma is a radioresistant cancer, and proton therapy is a promising radiation alternative for treating cancer with the advantage of a high dose concentration in the tumor area. In this work, we propose the use of iodine-substituted hydroxyapatite (IHAP) nanomaterials to use iodine (127I) as a proton radiation tracer, providing access to range verification studies in mineralized tissues. For this purpose, the nanomaterials were synthesized at four iodine concentrations via hydrothermal synthesis. The materials were characterized via different microstructural techniques to identify an optimal high iodine concentration and pure apatite phase nanomaterial. Finally, such pure IHAP powders were shaped and irradiated with proton beams of 6 and 10 MeV, and their activation was demonstrated through subsequent decay analysis. The materials could be integrated into phantom structures for the verification of doses and ranges of protons prior to animal testing and clinical proton therapy treatments of tumors located deep under combined soft and calcified tissues.},
language = {en},
urldate = {2024-11-21},
journal = {Journal of Materials Chemistry B},
author = {Hernández, R. Magro and Muñoz-Noval, A. and Briz, J. A. and Murias, J. R. and Espinosa-Rodríguez, A. and Fraile, L. M. and Agulló-Rueda, F. and Ynsa, M. D. and Sousa, C. Tavares de and Cortés-Llanos, B. and López, G. García and Nácher, E. and García-Tavora, V. and Geli, N. Mont i and Nerio, A. and Onecha, V. V. and Pallàs, M. and Tarifeño, A. and Tengblad, O. and Silván, M. Manso and Viñals, S.},
month = oct,
year = {2024},
file = {Full Text PDF:E:\Usuarios\Administrator\Zotero\storage\BBYUMTQV\Hernández et al. - 2024 - Iodine-substituted hydroxyapatite nanoparticles an.pdf:application/pdf},
}