by Andreia Granja, Rita Lima-Sousa, Cátia G. Alves, Duarte de Melo-Diogo, Cláudia Nunes, Célia T. Sousa, Ilídio J. Correia and Salette Reis
Abstract:
Photothermal therapy has emerged as a new promising strategy for the management of cancer, either alone or combined with other therapeutics, such as chemotherapy. The use of nanoparticles for multimodal therapy can improve treatment performance and reduce drug doses and associated side effects. Here we propose the development of a novel multifunctional nanosystem based on solid lipid nanoparticles co-loaded with gold nanorods and mitoxantrone and functionalized with folic acid for dual photothermal therapy and chemotherapy of breast cancer. Nanoparticles were produced using an economically affordable method and presented suitable physicochemical properties for tumor passive accumulation. Upon Near-Infrared irradiation (808 nm, 1.7 W cm−2, 5 min), nanoparticles could effectively mediate a temperature increase of textgreater20 °C. Moreover, exposure to light resulted in an enhanced release of Mitoxantrone. Furthermore, nanoparticles were non-hemolytic and well tolerated by healthy cells even at high concentrations. The active targeting strategy was found to be successful, as shown by the greater accumulation of the functionalized nanoparticles in MCF-7 cells. Finally, the combined effects of chemotherapy, light-induced drug release and photothermal therapy significantly enhanced breast cancer cell death. Overall, these results demonstrate that the developed lipid nanosystem is an efficient vehicle for breast cancer multimodal therapy.
Reference:
Andreia Granja, Rita Lima-Sousa, Cátia G. Alves, Duarte de Melo-Diogo, Cláudia Nunes, Célia T. Sousa, Ilídio J. Correia and Salette Reis, “Multifunctional targeted solid lipid nanoparticles for combined photothermal therapy and chemotherapy of breast cancer”, Biomaterials Advances, vol. 151, pp. 213443.
Bibtex Entry:
@article{granja_multifunctional_2023, title = {Multifunctional targeted solid lipid nanoparticles for combined photothermal therapy and chemotherapy of breast cancer}, volume = {151}, issn = {2772-9508}, url = {https://www.sciencedirect.com/science/article/pii/S2772950823001668}, doi = {10.1016/j.bioadv.2023.213443}, abstract = {Photothermal therapy has emerged as a new promising strategy for the management of cancer, either alone or combined with other therapeutics, such as chemotherapy. The use of nanoparticles for multimodal therapy can improve treatment performance and reduce drug doses and associated side effects. Here we propose the development of a novel multifunctional nanosystem based on solid lipid nanoparticles co-loaded with gold nanorods and mitoxantrone and functionalized with folic acid for dual photothermal therapy and chemotherapy of breast cancer. Nanoparticles were produced using an economically affordable method and presented suitable physicochemical properties for tumor passive accumulation. Upon Near-Infrared irradiation (808 nm, 1.7 W cm−2, 5 min), nanoparticles could effectively mediate a temperature increase of {textgreater}20 °C. Moreover, exposure to light resulted in an enhanced release of Mitoxantrone. Furthermore, nanoparticles were non-hemolytic and well tolerated by healthy cells even at high concentrations. The active targeting strategy was found to be successful, as shown by the greater accumulation of the functionalized nanoparticles in MCF-7 cells. Finally, the combined effects of chemotherapy, light-induced drug release and photothermal therapy significantly enhanced breast cancer cell death. Overall, these results demonstrate that the developed lipid nanosystem is an efficient vehicle for breast cancer multimodal therapy.}, urldate = {2024-05-21}, journal = {Biomaterials Advances}, author = {Granja, Andreia and Lima-Sousa, Rita and Alves, Cátia G. and de Melo-Diogo, Duarte and Nunes, Cláudia and Sousa, Célia T. and Correia, Ilídio J. and Reis, Salette}, month = aug, year = {2023}, keywords = {Breast cancer, Folic acid, Gold nanorods, Mitoxantrone, Multimodal therapy, Solid lipid nanoparticles}, pages = {213443}, file = {ScienceDirect Snapshot:E:\Usuarios\Administrator\Zotero\storage\3453USGJ\S2772950823001668.html:text/html;Texto completo:E:\Usuarios\Administrator\Zotero\storage\BAN8B8EL\Granja et al. - 2023 - Multifunctional targeted solid lipid nanoparticles.pdf:application/pdf}, }