by Sara C. Freitas, João H. Belo, Andreia Granja, Miguel Canhota, Ana S. Silva, Salette Reis, Helder Crespo, João P. Araújo and Célia T. Sousa
Abstract:
As nanoparticle formulations move toward human clinical trials in photothermal cancer therapy (PTT), the influence of individual key parameters on the heating efficacy must be thoroughly assessed. This work reports a systematic study on the heating performance of gold nanorods during exposure to near-infrared radiation, evaluating the influence of nanorods concentration, total volume, laser output power, and spot area. Interestingly, the lowest concentration tested (24 µg mL−1) shows the most promising results with a SAR (Specific Absorption Rate) value of 24.6 kW gAu−1 for the highest laser power (0.8 W), spot area (0.4 cm2), volume (1 mL). The laser output power and concentration proved to be the key parameters in global heating of the sample. The cuvette’s optical path length also proves to be an important parameter given that there is a threshold concentration value beyond which no significant improvement will be observed, and the higher gold mass will play a detrimental role suppressing SAR values. It is experimentally demonstrated that the multi-parameter exploration can lead to a finer control of the performance in PTT, opening a pathway for efficient heating of low nanoparticle concentrations.
Reference:
Sara C. Freitas, João H. Belo, Andreia Granja, Miguel Canhota, Ana S. Silva, Salette Reis, Helder Crespo, João P. Araújo and Célia T. Sousa, “Key Parameters in Phototherapy with Gold Nanorods Using Continuous Near Infrared Radiation”, Advanced Materials Interfaces, vol. 10, no. 14, pp. 2202214.
Bibtex Entry:
@article{freitas_key_2023,
title = {Key {Parameters} in {Phototherapy} with {Gold} {Nanorods} {Using} {Continuous} {Near} {Infrared} {Radiation}},
volume = {10},
copyright = {© 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH},
issn = {2196-7350},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/admi.202202214},
doi = {10.1002/admi.202202214},
abstract = {As nanoparticle formulations move toward human clinical trials in photothermal cancer therapy (PTT), the influence of individual key parameters on the heating efficacy must be thoroughly assessed. This work reports a systematic study on the heating performance of gold nanorods during exposure to near-infrared radiation, evaluating the influence of nanorods concentration, total volume, laser output power, and spot area. Interestingly, the lowest concentration tested (24 µg mL−1) shows the most promising results with a SAR (Specific Absorption Rate) value of 24.6 kW gAu−1 for the highest laser power (0.8 W), spot area (0.4 cm2), volume (1 mL). The laser output power and concentration proved to be the key parameters in global heating of the sample. The cuvette's optical path length also proves to be an important parameter given that there is a threshold concentration value beyond which no significant improvement will be observed, and the higher gold mass will play a detrimental role suppressing SAR values. It is experimentally demonstrated that the multi-parameter exploration can lead to a finer control of the performance in PTT, opening a pathway for efficient heating of low nanoparticle concentrations.},
language = {en},
number = {14},
urldate = {2024-05-21},
journal = {Advanced Materials Interfaces},
author = {Freitas, Sara C. and Belo, João H. and Granja, Andreia and Canhota, Miguel and Silva, Ana S. and Reis, Salette and Crespo, Helder and Araújo, João P. and Sousa, Célia T.},
year = {2023},
keywords = {phototherapy, continuous laser, gold nanorods, oncology},
pages = {2202214},
file = {Full Text PDF:E:\Usuarios\Administrator\Zotero\storage\KERZXFAZ\Freitas et al. - 2023 - Key Parameters in Phototherapy with Gold Nanorods .pdf:application/pdf;Snapshot:E:\Usuarios\Administrator\Zotero\storage\3X5XY8BY\admi.html:text/html},
}