by Vital Cruvinel Ferreira-Filho, Beatriz Morais, Bruno J. C. Vieira, João Carlos Waerenborgh, Maria João Carmezim, Csilla Noémi Tóth, Sandra Même, Sara Lacerda, Daniel Jaque, Célia T. Sousa, Maria Paula Cabral Campello and Laura C. J. Pereira
Abstract:
This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.
Reference:
Vital Cruvinel Ferreira-Filho, Beatriz Morais, Bruno J. C. Vieira, João Carlos Waerenborgh, Maria João Carmezim, Csilla Noémi Tóth, Sandra Même, Sara Lacerda, Daniel Jaque, Célia T. Sousa, Maria Paula Cabral Campello and Laura C. J. Pereira, “Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile”, Molecules, vol. 29, no. 8, pp. 1824.
Bibtex Entry:
@article{ferreira-filho_influence_2024-1,
	title = {Influence of {SPION} {Surface} {Coating} on {Magnetic} {Properties} and {Theranostic} {Profile}},
	volume = {29},
	copyright = {http://creativecommons.org/licenses/by/3.0/},
	issn = {1420-3049},
	url = {https://www.mdpi.com/1420-3049/29/8/1824},
	doi = {10.3390/molecules29081824},
	abstract = {This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.},
	language = {en},
	number = {8},
	urldate = {2024-11-26},
	journal = {Molecules},
	author = {Ferreira-Filho, Vital Cruvinel and Morais, Beatriz and Vieira, Bruno J. C. and Waerenborgh, João Carlos and Carmezim, Maria João and Tóth, Csilla Noémi and Même, Sandra and Lacerda, Sara and Jaque, Daniel and Sousa, Célia T. and Campello, Maria Paula Cabral and Pereira, Laura C. J.},
	month = jan,
	year = {2024},
	keywords = {gadolinium, gold nanoparticles, hyperthermia, iron oxides nanoparticles, magnetic resonance imaging, superparamagnetism},
	pages = {1824},
	file = {Full Text PDF:E:\Usuarios\Administrator\Zotero\storage\ATEDBC2B\Ferreira-Filho et al. - 2024 - Influence of SPION Surface Coating on Magnetic Pro.pdf:application/pdf},
}