by Carina Marques Coelho, Lia Pereira, Pamela Teubig, Pedro Santos, Filipa Mendes, Sílvia Viñals, Daniel Galaviz and Federico Herrera
Abstract:
Radiotherapy (RT) is a relatively safe and established treatment for cancer, where the goal is to kill tumoral cells with the lowest toxicity to healthy tissues. Using it for disorders involving cell loss is counterintuitive. However, ionizing radiation has a hormetic nature: it can have deleterious or beneficial effects depending on how it is applied. Current evidence indicates that radiation could be a promising treatment for neurodegenerative disorders involving protein misfolding and amyloidogenesis, such as Alzheimer’s or Parkinson’s diseases. Low-dose RT can trigger antioxidant, anti-inflammatory and tissue regeneration responses. RT has been used to treat peripheral amyloidosis, which is very similar to other neurodegenerative disorders from a molecular perspective. Ionizing radiation prevents amyloid formation and other hallmarks in cell cultures, animal models and pilot clinical trials. Although some hypotheses have been formulated, the mechanism of action of RT on systemic amyloid deposits is still unclear, and uncertainty remains regarding its impact in the central nervous system. However, new RT modalities such as low-dose RT, FLASH, proton therapy or nanoparticle-enhanced RT could increase biological effects while reducing toxicity. Current evidence indicates that the potential of RT to treat neurodegeneration should be further explored.
Reference:
Carina Marques Coelho, Lia Pereira, Pamela Teubig, Pedro Santos, Filipa Mendes, Sílvia Viñals, Daniel Galaviz and Federico Herrera, “Radiation as a Tool against Neurodegeneration—A Potential Treatment for Amyloidosis in the Central Nervous System”, International Journal of Molecular Sciences, vol. 23, no. 20, pp. 12265.
Bibtex Entry:
@article{coelho_radiation_2022,
title = {Radiation as a {Tool} against {Neurodegeneration}—{A} {Potential} {Treatment} for {Amyloidosis} in the {Central} {Nervous} {System}},
volume = {23},
copyright = {https://creativecommons.org/licenses/by/4.0/},
issn = {1422-0067},
url = {https://www.mdpi.com/1422-0067/23/20/12265},
doi = {10.3390/ijms232012265},
abstract = {Radiotherapy (RT) is a relatively safe and established treatment for cancer, where the goal is to kill tumoral cells with the lowest toxicity to healthy tissues. Using it for disorders involving cell loss is counterintuitive. However, ionizing radiation has a hormetic nature: it can have deleterious or beneficial effects depending on how it is applied. Current evidence indicates that radiation could be a promising treatment for neurodegenerative disorders involving protein misfolding and amyloidogenesis, such as Alzheimer’s or Parkinson’s diseases. Low-dose RT can trigger antioxidant, anti-inflammatory and tissue regeneration responses. RT has been used to treat peripheral amyloidosis, which is very similar to other neurodegenerative disorders from a molecular perspective. Ionizing radiation prevents amyloid formation and other hallmarks in cell cultures, animal models and pilot clinical trials. Although some hypotheses have been formulated, the mechanism of action of RT on systemic amyloid deposits is still unclear, and uncertainty remains regarding its impact in the central nervous system. However, new RT modalities such as low-dose RT, FLASH, proton therapy or nanoparticle-enhanced RT could increase biological effects while reducing toxicity. Current evidence indicates that the potential of RT to treat neurodegeneration should be further explored.},
language = {en},
number = {20},
urldate = {2024-11-29},
journal = {International Journal of Molecular Sciences},
author = {Coelho, Carina Marques and Pereira, Lia and Teubig, Pamela and Santos, Pedro and Mendes, Filipa and Viñals, Sílvia and Galaviz, Daniel and Herrera, Federico},
month = oct,
year = {2022},
pages = {12265},
file = {Texto completo:E:\Usuarios\Administrator\Zotero\storage\8DN7SPGM\Coelho et al. - 2022 - Radiation as a Tool against Neurodegeneration—A Po.pdf:application/pdf},
}