Seminars at the Accelarator - Laser Induced Synthesis of Biocompatible Nanoparticles
30.05.2016 - 30.05.2016
CMAM - Madrid
Seminarios informales en el Acelerador


Ponente: Oscar Bomatí Miguel, UAM

Titulo: Laser Induced Synthesis of Biocompatible Multifunctional Inorganic Nanoparticles: A Novel Route to Produce Multifunctional Contrast Agents for Early Diagnosis of Breast Cancer. 

Abstract: Breast cancer is the most frequently diagnosed cancer in women worldwide. About 1.7 million new cases and 522,000 women deaths were reported in 2012. Breast cancer diagnosis involves physical examination, detection of suspicious masses via imaging screening, and entails tissue sampling to make a definitive diagnosis. Nowadays, multimodal diagnosis by combining several imaging techniques, such as mammography, ultrasonography, magnetic resonance imaging and computed X-ray tomography, is playing a leading role in the diagnosis of breast cancer. However clinical application of this approach is still problematic due the lack of appropriate contrast agents showing capabilities to distinguish between malignant tumors and benign abnormal masses.

The main goal of the NIMBLIS project is to fabricate novel nanoparticle-based multimodal contrast agents designed specifically for their use in breast cancer screening by combining magnetic resonance imaging, ultrasonography and X-ray imaging techniques. Nanoparticles designed for their use as contrast agents requires satisfy strict criteria, such as: appropriate size, biocompatibility, high contrast efficacy, long blood circulation time, and long-term colloidal stability in the physiological environment, and cost effectiveness. However, chemical procedures used in laboratory to synthesize multimodal nanoparticles are not well standardized and cost-effective methods to produce large quantities of these nanoparticles. Therefore, we will develop a new synthesis method, which consists in the laser ablation of ceramic plates, sowing the same composition of the projected multimodal nanoparticles. This synthesis process is a green process, which allows the production of different types of nanoparticles with minor procedure changes, minimal manual operation,
raw materials are used for the synthesis, and minimum waste production.

As synthesized multimodal nanoparticles will be functionalized with Trastuzumab and targeted toward the human epidermal growth factor receptor 2 (HER2), which is overexpressed in breast cancers with poor prognosis and higher recurrence. In the case of positive results, the use of these multimodal contrast agents in clinical practice would improve breast cancer diagnosis (greater sensitivity and specificity), allowing a selection
of patients who may respond to trastuzumab therapy without the need of a biopsy.



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El seminario tendrá lugar en la sala de reuniones del CMAM